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KMID : 0606920100180030257
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Biomolecules & Therapeutics
2010 Volume.18 No. 3 p.257 ~ p.261
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Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite
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Chang Soo-Im
Ryu Doug-Young
Kim Soo-Hee
Park Jung-Duck
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Abstract
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While it’s been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.
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KEYWORD
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Arsenic, Testis, Testosterone, Mouse
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